Research

In research in the synthetic biology field, I look at how genetic information's spatial location plays a role in single-cell system dynamics. It is seen that increasing the distance of two parts of a simple pathway can drastically affect its dynamics. When I think of the spatial organisation of the transcribed components, especially small proteins, it seems to me that diffusion on the scale of an E.Coli would cause this organisation to be a short transient process. This would lead to the conclusion that spatial organisation effects are not significant over a protein lifetime. These conflicting observations attracted me to find what is causing this dissonance of this initial model and experiment. I have developed a model consolidating these observations using mathematics and data science, as seen in the publications below.

Publications

• A model for the spatio-temporal design of gene regulatory circuits
• Modelling co-translational dimerization for programmable nonlinearity in synthetic biology
• FlowScatt: enabling volume-independent flow cytometry data by decoupling fluorescence from scattering
• Pathways to cellular supremacy in biocomputing
• Contextual dependencies expand the re-usability of genetic inverters